Transcriptional profiling of growing and senescent WT and IL-1R-depleted IMR90 cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=29cc24c30f7db0c529ee00bbce0f6c34
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资源简介：
Senescent cells no longer divide, but remain metabolically active and secrete an array of cytokines, growth factors, and proteases termed the senescence-associated secretory phenotype (SASP). Previous studies have indicated that the SASP factor IL-1α may be an upstream regular of the SASP. We show here that knockdown of the IL-1α receptor IL-1R results in a sizable reduction of SASP expression late in senescence induction. Our results suggest that targeting the IL-1 signaling pathway is a reliable method to dissociate the SASP from cell-cycle exit.
提供机构：
NYU School of Medicine
创建时间：
2022-02-20
