WhichTF and active TF identification (ATI) results for mouse data.

The ATI experiment identifies active TFs, by quantifying the total number of TF-DNA binding events in cells or tissues, performing sequencing and computational motif identification on TF-bound DNA to identify TF families, and distinguishing individual TFs through mass spectrometry. ATI identified active transcription factor families across five cell types (ES cells, heart, spleen, brain, and liver) and classified TFs into common TFs found in all five types, shared TFs found in more than two types, and specific TFs found in one or two cell types (PMID: 29786094). The top 5 WhichTF TFs with their corresponding ENCODE accession IDs and statistical significance (conditional probability), are shown for mouse (a) B-cells, (b) T-cells, (c) heart cells, and (d) hindbrain cells. ATI results are shown for the two most overlapping cell types, heart and brain. The importance and PubMed ID (PMID) columns indicate whether (i) existing literature supports the identified TFs (confirmed); (ii) literature reports closely related factors, such as co-factors and functionally related family members, or the identified TFs in a related context (suggestive); or (iii) novel. For the ATI assay, we report importance as identified in their original publication [PMID: 29786094]. WhichTF and ATI highlight mostly confirmed but largely complementary results. (XLSX)