Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta
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https://figshare.com/articles/dataset/Limonoids_and_Triterpenoids_as_11_HSD1_Inhibitors_from_Walsura_robusta/3081796
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资源简介：
Nine new cedrelone-type limonoid
derivatives, walsunoids A–I
(1–9), and 11 known compounds were
isolated from the leaves of Walsura robusta. Walsunoid A (1) is a new degradation product of cedrelone-type
limonoids, and walsunoid I (9) is a rare cedrelone-type
limonoid amide. Their structures and absolute configurations were
determined by spectroscopic data, single-crystal X-ray diffraction,
and ECD data analyses. Five compounds showed moderate inhibitory activities
against human and/or mouse 11β-hydroxysteroid dehydrogenase
type 1 (11β-HSD1) with IC50 values ranging from 0.69
to 9.9 μM.
创建时间：
2016-04-18
