Analyze the transcriptional signature of human primary culture of CD133+ CD24+ renal progenitor cells

Podocytes and podocyte progenitors are interdependent components of the kidney's glomerular structure, with podocytes forming the glomerular filtration barrier and progenitors being key players in podocyte regeneration during pathophysiological processes. Both cell types are subjected to constant mechanical forces, whose alterations can initiate podocytopathy and worsen glomerular injury. Despite this, the specific mechanosensors and mechanotransduction pathways involved in their response to mechanical cues remain only partially explored. The role of Piezo1 silencing is studied in this dataset. In this dataset we analyzed 3 primary cell culture treated with LNA scramble or LNA Piezo1 Gapmer. 3 primary cell culture were transfected with LNA scramble or LNA Piezo1 Gapmer antisense oligonucluotide.