Cell communication within tissues is mediated by multiple paracrine signals including growth factors, which control cell survival and proliferation. Cells and the growth factors they produce and recei
Aggregation of cell surface receptor proteins by multivalent antigens is an essential early step for immune cell signaling. A number of experimental and modelling studies in the past have investigated
1In this and other tables (and in text) a dual notation is used: roman (e.g. PKC) for a species and italic (e.g. PKC) for its concentration. 2For all other variables (L0, LN0, RL0, R*0, G*0, Gb0, Gr0,
VNPR-A was estimated from the initial slope of ANP-induced cGMP accumulation in the presence of 500 μM IBMX. Vmax-PDE and Vmax-PDEs were estimated from data in Figures 7D,E, cell count, and an estimat
Field description: ID: Numeric IDs of the models as they are referred in the text. Specific Biosystem: Biosystem mapped by the model. Network Topology: Upstream pathway or feedback involved in the mod