Cytochrome c′ from Rhodobacter capsulatus Confers Increased Resistance to Nitric Oxide

We report the cloning and sequencing of the gene containing cytochrome c′ (cycP) from the photosynthetic purple bacterium Rhodobacter capsulatus and the regions flanking that gene. Mutant strains unable to synthesize cytochrome c′ had increased sensitivity to nitrosothiols and to nitric oxide (which binds to the heme moiety of cytochrome c′).