Environment-responsive transcription factors bind proto-silencer elements and regulate subtelomeric silencing

Subtelomeric chromatin is subject to evolutionarily conserved complex epigenetic regulation and is implicated in numerous aspects of cellular function including formation of heterochromatin, regulation of different stress response pathways, and control of lifespan亚端粒染色质（Subtelomeric chromatin）受到进化保守的复杂表观遗传调控，并参与细胞功能的诸多方面，包括异染色质形成、不同应激反应通路的调控以及寿命控制