Childhood acute lymphoblastic leukemia (cALL) is the most frequent pediatric cancer. Refractory/ relapse cALL presents a survival rate of about 45% and is still one of the leading causes of death by d

NIAID Data Ecosystem70

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells

乳腺癌

克隆动态

Most human breast cancers have already diversified genomically when they first become clinically evident, by which time extensive heterogeneous histopathologies, transcriptomes and growth patterns are

NIAID Data Ecosystem50

High-complexity cellular barcoding identifies clonal substitution as a hallmark of local recurrence in a surgical model of head and neck cancer. HNSCC RTICs Exome Sequencing

肿瘤复发机制

克隆动态

The survival prognosis for head and neck squamous cell carcinoma (HNSCC) remains dismal mainly because of insufficient local and loco-regional control resulting in a significant number of treatment fa

NIAID Data Ecosystem80

Parasites driving host diversity: incidence of disease correlated with Daphnia clonal turnover

宿主-寄生虫共进化

克隆动态

According to the Red Queen hypothesis, clonal diversity in asexual populations could be maintained by negative frequency-dependant selection by co-evolving parasites. If common clones are selected aga

DataONE2020-06-24 更新70

Mutational signatures and clonal dynamics in normal human tissues

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