ToxR Transmembrane Domain Sequences.

Residues in regular font style are encoded by the reading frame of the plasmid constructs, capitalized bold residues are the transmembrane domain sequences studied. GpA is the glycophorin A transmembrane domain previously studied and known to have strong homotypic interactions [45], [47], [48]. TLR1-TLR10 are the transmembrane domains of the specified Toll-like receptor as identified by hydrophobic analysis. TMD5 and Integrin αIIb are unrelated TMD receptors used for studying TLR specificity. Sequences of GpA, TLR2, TLR7, TLR9, and Integrin αIIb all contain Small-XXX-Small motifs that have been indicated as bold italicized letters.