CD4+ CAR-T cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR-T cell therapy

NIAID Data Ecosystem2026-05-02 收录

CAR-T细胞耗竭

多发性骨髓瘤复发

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274187 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-08-08

Clonal selection and double hit events involving tumor suppressor genes underlie relapse from chemotherapy: myeloma as a model

多发性骨髓瘤复发

肿瘤抑制基因失活

To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma we performed a longitudinal study of 33 patients entered into Total Therapy protocols investigating them using gene

NIAID Data Ecosystem80

Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome

癌症代谢组学

多发性骨髓瘤复发

Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of malignant plasma cells. Though durable remissions are possible, MM is considered incurable, with

NIAID Data Ecosystem40

mRNA Profiling of Chronically Stimulated CART19-28z Cells in the Manuscript IL-4 Drives Exhaustion of CD8+ CART Cells

CAR-T细胞耗竭

免疫疗法优化

Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independ

NIAID Data Ecosystem20

BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells (ATAC-seq)

CAR-T细胞耗竭

ATAC-seq表观遗传学

Cooperative interactions among transcription factors are essential for gene transcription. We previously showed that NFAT and AP-1 (Fos-Jun) transcription factors cooperate to promote the effector fun

NIAID Data Ecosystem60

Integrative analysis of DNA copy number, DNA methylation and gene expression in multiple myeloma reveals alterations related to relapse [gene expression]. Homo sapiens

多发性骨髓瘤复发

多组学整合分析

Multiple myeloma (MM) remains incurable despite the introduction of novel agents and a relapsing course is observed in the majority of patients. Although the development of genomic technologies has gr

NIAID Data Ecosystem30

CD4+ CAR-T cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR-T cell therapy

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