Novel Interplay between Skin Microbiota and Plasma Metabolite in Psoriasis

Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. There's till no effective approach for the clinical treatment of psoriasis. It is largely due to the lack of understanding on the pathological mechanism. Here, we characterized the skin microbiome and plasma metabolome alterations of psoriasis people comprehensively. We observed some pathological bacteria, including vibrio, were significantly increased in psoriasis patients. The metabolomics results showed the alteration of some metabolic pathways, especially pathways for lipid metabolism. In addition, microbiome specific metabolites, including bile acids and kynurenine, were also significantly changed. Correlation analysis revealed the interplay between skin microbiota and plasma metabolites, especially highlighted the relationship between vibrio and several lipids. Our results provide new evidence for the interplay between skin microbiome and plasma metabolite, which is dramatically disrupted in psoriasis patients. This study also revealed the underlying mechanism of pathogenesis for psoriasis.