Brain microvessel-specific transcriptome profiling after severe cerebral hypoperfusion in mice

Little is understood about the underlying cellular and molecular mechanisms related to brain microvessel damage and glial activation after severe cerebral hypoperfusion. Efforts to explore the relationship between neuropathological and gene expression changes support a role for identifying novel molecular pathways by transcriptomic mechanisms. Overall design: To investigate brain microvessel-specific transcriptome profiling after severe cerebral hypoperfusion in mice Brain microvessel-specific gene expression profiling analysis was performed using data obtained from RNA-seq of 3 biological replicates in sham and BCAS mice after hypoperfusion