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single cell RNA-seq of mice synovium

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP370515
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Purpose: Joint function is impaired by disuse. We investigated mice synovium for control and MMS(minimized mechanical stress) model mice. Method: We developed a MMS model which could represent the disused joint by combining non-weight bearing with tail suspension and knee joint immobilization with a plastic cylinder. We obtained synovial cells from control and MMS day14 mice. Conclusion: Specific subsets in MMS synovium expressed many secreted proinflammatory cytokines and are thought to be the tragger of cartilage degeneration.. Overall design: single cell RNA-seq of synovium in control and MMS model mice
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2026-02-03
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