Paternal exposure to Arctic contaminants alters the sperm epigenome and induces negative pregnancy outcomes transgenerationally. Paternal exposure to Arctic contaminants alters the sperm epigenome and induces negative pregnancy outcomes transgenerationally

Paternal exposure to environmentally-relevant Arctic contaminants induces adverse health outcomes and alters the sperm methylome over three generations. Overall design: Genome-wide methylation profiles of rat epididymal sperm across F1, F2 and F3 generations spermatozoa profiles (6 organochlorines exposed and 6 controls per generation)