Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA284278
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资源简介：
We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming. Overall design: To investigate the gene expression profiles of MEFs and to find out the potential genes responsible for the improvement of Dnmt3l-KO cloned embryos.
创建时间：
2015-05-18
