aAs defined by the 2006 census (per capita income less than twice the value of a standardized basic basket of food) [57].bRepresents total sample per trial arm at baseline. There were small amounts of
— = no data provided; NA = not available ; RCT = randomized-controlled trials; LOE = level of evidence; BSS: balanced saline solution.aThe part included in the partly retrospective study is retrospect
Baseline characteristics in the per-protocol population: Age, sex and MTHFR polymorphisms C677T (rs1801133) and A1289C (rs1801131) (data for modified intention-to-treat population in S2 Table).
