Role of Capicua in metabolic system. Mus musculus

CIC is a HMG box-containing transcriptional repressor evolutionarily conserved from C. elegans to human. It's known to associate with various types of cancer but physiological function of CIC remain largely unknown. In this study, we characterized Cic hypomorphic (Cic-L-/-) mice and identified critical roles for of CIC in drug metabolism and bile acid homeostasis. Overall design: Total RNA obtained from isolated liver tissue of Cic-L-/- mouse compared to liver tissue of normal mouse