首页/数据集/Raw data-Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model

Raw data-Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model

NIAID Data Ecosystem2026-03-13 收录

ALS病理机制

神经保护靶点

数据链接：

https://data.mendeley.com/datasets/s4vmtjkxc4 数据链接链接失效反馈

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资源简介：

raw data of the research work

应用场景：

创建时间：

2022-03-23

ALS病理机制

表观遗传调控

Additional file 2: Table S1. Integrated analysis of RNA-sequencing and H3K4me2 ChIP-sequencing to identify spermidine-modulated gene signatures in ALS (G93A).

Figshare2023-04-13 更新50

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

ALS病理机制

TBK1基因功能

DNA sequence variants in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS). Here we show that mice bearing human ALS-associated TBK1 missense loss-of-funct

NIAID Data Ecosystem40

A low level of expression of C-terminally truncated human FUS causes extensive changes in the spinal cord transcriptome of asymptomatic transgenic mice

ALS病理机制

转录组分析

A number of mutations in a gene encoding RNA-binding protein FUS was linked to the development of a familial form of amyotrophic lateral sclerosis known a FUS-ALS. C-terminal truncations of FUS by a n

NIAID Data Ecosystem00

Structure of pathological TDP-43 filaments from ALS with FTLD

TDP-43蛋白

ALS病理机制

Structure of pathological TDP-43 filaments from ALS with FTLD Descriptor: TAR DNA-binding protein 43 Authors: Arseni, D, Hasegawa, H, Murzin, A.G, Kametani, F, Arai, M, Yoshida, M, Falcon, B. Deposit

Protein Data Bank Japan2024-07-17 更新50

Neuromuscular Junction Innervation and Motor Function Are Preserved by Restoring Muscarinic Signaling in Perisynaptic Glia in ALS, Tremblay et al. - Figure 8 - GFAP and Iba1

ALS病理机制

神经细胞标记

Raw data and analysis file for Figure 8 - Panel c, d and e (GFAP and Iba1) and Figure S1

DataCite Commons2026-03-20 更新30