Gene activation by Rag-mediated DNA double-strand breaks in G1-phase murine pre-B cells

ChEBI2013-03-13 更新2026-07-21 收录

V(D)J重组

B细胞发育

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-38044 数据链接链接失效反馈

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Gene activation by Rag-mediated DNA double-strand breaks in G1-phase murine pre-B cells

创建时间：

2013-03-13

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B细胞发育

信号转导分析

We examined the global gene expression profile of PLCγ1/PLCγ2 double-deficient CLPsand B cell progenitors by RNA-seq analysis. Overall design: CLPs (Lin-IL-7R+) and B cell progenitors (B220+IgM-IL-7R+

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Expression data from long-term Ebf1-deficient, CD19+, Bcl2tg cells

基因表达

B细胞发育

An assessment of a role of Ebf1 in committed B lineage cells. In this study, we adopted the strategy of deleting Ebf1 after reconstitution of Rag2-/-Il2rg-/- mice and found that committed pre-B cells

NIAID Data Ecosystem70

Igk locus capture-based target enrichment sequencing. Igk locus capture-based target enrichment sequencing

V(D)J重组

DNA双链断裂修复

Cell cycle is a major determinant of DNA double-strand break (DSB) repair pathway choice with homologous recombination (HR) that is most active in S phase cells and non-homologous end-joining (NHEJ) t

NIAID Data Ecosystem50

The RAG-HMG1 Complex Enforces the 12/23 Rule of V(D)J Recombination Specifically at the Double-Hairpin Formation Step

V(D)J重组

淋巴细胞受体基因重组

A central unanswered question concerning the initial phases of V(D)J recombination has been at which step the 12/23 rule applies. This rule, which governs which variable (V), diversity (D), and joinin

PubMed Central70

The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement

B细胞发育

剪接体功能

The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and

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Gene activation by Rag-mediated DNA double-strand breaks in G1-phase murine pre-B cells

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