Regulated endocleavage balances the degradation of nonsense-mediated decay substrates. Regulated endocleavage balances the degradation of nonsense-mediated decay substrates
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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB9541
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资源简介：
Nonsense-mediated mRNA decay (NMD) controls gene expression by eliminating mRNAs with premature or aberrant translation termination. Degradation of NMD substrates is initiated by the central NMD factor UPF1, which recruits the endonuclease SMG6 and the deadenylation-promoting SMG5/7 complex. Here we map transcriptome-wide sites of SMG6-mediated endocleavage via 3′ fragment capture and degradome sequencing.
创建时间：
2016-10-16
