File S1 - Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Contains the files: Figure S1 Modeling structure of the Plk1-PBD, which shows the presence of the phosphate binding pocket, pyrrolidine binding pocket and Try rich hydrophobic channel. Figure S2 Solid phase synthesis of FITC conjugated derivative of bg-34. Table S1 Inhibitory activity of Plk1 PBD by compounds PLHSpT, PPG, PLS1-PLS3, PLS5, Bg-1, Bg-2, bg-27- Bg-30, Bg-33 and Bg-34. Table S2 HPLC retention time, % of purity and MALDI-TOF mass values of bg-33, bg-1, bg-2, bg5, bg-6, bg-2, bg-28, bg-29, bg-30 and bg-34 molecules.
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