Predictive value of drug elimination gene polymorphisms on clearance and dose adjustment of sunitinib (Sutent, SU11248) in patients with cancer

Primary objectives: To observe the correlation between ABCB1 polymorphisms in Exons 13, 22 and 27 and the clearance of sunitinib at steady state.
Primary endpoints: The endpoint of the study is a correlation between sunitinib clearance and toxicityadjusteddose with ABCB1 genotype examining SNPs in exons 13, 22,and 27 as wellas haplotypes of these exons.