Comparison of COG distribution in the virulence genes with the B. melitensis 16 M genome COG distribution.

P value obtained with chi-squared test and Fisher exact test,*p-value ≤0.05. Abbreviations: COG: cluster of orthologous groups, A: RNA processing and modification, B: chromatin structure and dynamics, C: energy production and conversion, D: cell cycle control, cell division, chromosome partitioning, E: amino acid transport and metabolism, F: nucleotide transport and metabolism, G: carbohydrate transport and metabolism, H: coenzyme transport and metabolism, I: lipid transport and metabolism, J: translation, ribosomal structure and biogenesis, K: transcription, L: replication, recombination and repair, M: cell wall/membrane/envelope biogenesis, N: cell motility, NC: not in COG, O: posttranslational modifications, protein turnover, chaperones, P: inorganic ion transport and metabolism, Q: secondary metabolites biosynthesis, transport and catabolism, R: general function prediction only, S: function unknown, T: signal transduction mechanisms, U: intracellular trafficking, secretion and vesicular transport, V: defense mechanisms, W: extracellular structures.