Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

Reducing mitochondrial electron transport induces a Warburg-like shift to accommodate for the energetic burden caused by brain trauma without overwhelming mitochondrial cellular respiration and cellular redox to salvage dopaminergic neurons. This metabolic shift is evident in the transcriptional upregulation of key genes in the Pyruvate Dehydrogenase Complex and glycolytic pathway. Age-matched, 10 week old Surf1+/+ and Surf1-/- mouse brains were harvested and single nuclei preps were submitted for sequencing.