Discovery of reversible selective MAO-B inhibitors with anti-AChE activity derived from 4-oxo-N, 4-diphenyl butanamides - Supplementary Material

Table S1. Docking results of 4-oxo-N, 4-diphenyl butanamides against AChE, and MAOs.

Table S2. Calculated physiochemical descriptors of 4-oxo-N, 4-diphenyl butanamides using QikProp

Table S3 Compound purity by HPLC (method):

Figure S1. HPLC Chromatogram (tR, 3.007 min) of compound 6h at 250 nm.

Table S4 Permeability of nine commercial drugs used for validation of PAMPA-BBB assay

Figure S2. Linear correlation chart of experimental and literature reported permeability of commercial drugs for PAMPA-BBB assay.

Table S5. Permeability of 4-oxo-N, 4-diphenyl butanamides determined by BBB-PAMPA assay

Table S6. Cell viability and neuroprotection of synthesized compounds on SH-SY5Y cell line

1H & 13C NMR spectra of Synthesised compounds: