lncRNA and mRNA in a septic acute lung injury mouse model

Sepsis is commonly complicated by acute lung injury (ALI). We aimed to determine the long noncoding RNAs (lncRNAs) and mRNAs expression profiles in a cecal ligation and puncture mouse model of septic ALI. The model was verified by the elevation of inflammatory cytokine levels, the protein concentration in Bronchoalveolar lavage fluid and histological analysis of lung tissues. LncRNA and mRNA profiles were detected using an Agilent microarray. Bioinformatic analyses were employed to analyze the expression profiles and multiple biological functions. The results showed that lncRNAs These results implied that lncRNAs would be novel regulators and potential targets in septic ALI. we divided 6-8 weeks mice into two groups - control and septic model and 6 mice per group.