List of the statistically overrepresented transcriptional regulators (TRs) obtained per independent component (IC) after removing first line of variance.

Three ICs (IC2, IC3 and IC4) among the computed five components show enriched TRs. TR symbol and name are indicated for each TR in the list. Gene:Bg Ratio indicates the number of target genes (TGs) regulated by the specific TR among the 509 major contributor genes versus the number of TGs regulated by the TR within the background. Only those major contributors that appear in the customized TR database obtained from Open Regulatory Annotation (ORA) database per IC are considered (i.e. for IC2, 489 out of the 509 contributors). Background considers 4,772 genes included in the customized ORA database for TR Enrichment Analysis (TREA) among 5,084 differential genes. TRs are sorted based on their adj p-val (FDR correction) coded as *** < 0.001, ** < 0.01, * < 0.05 and—in case > 0.05. Last column indicates the adj p-val obtained from Differential Gene Expression Analysis (DGEA).