Supporting data for "Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly"
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https://archive.researchdata.leeds.ac.uk/921/
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资源简介：
Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to study the mechanism of amyloid assembly of wild-type hIAPP and its more amyloidogenic natural variant S20G. We also report the discovery of two structurally distinct small-molecule modulators of hIAPP assembly.
提供机构：
University of Leeds
创建时间：
2022-01-31
