iPSC-derived Human Intestinal Organoids are permissive to SARS-CoV-2 infection

We performed transcriptomic profiling of cells derived from human induced pluripotent stem cells (iPSCs) using a directed differentiation protocol to generate mesenchyme free, regionally patterned intestinal organoids. These organoids were then infected with SARS-CoV-2, and sequencing was performed 1 and 4 days post infection Global transcriptomic analysis of PSC-derived intestinal organoids infected with SARS-CoV-2 omparing 1 and 4 days post infection to matched mock controls in both proximal and distally patterned infestinal organoids. (n=3 per condition)