CUT Tag profiling of histone H3K9 lactylation in macrophages after spinal cord injury

his study aimed to investigate the role of histone lactylation in macrophage-mediated neuroinflammation after spinal cord injury (SCI). Using CUTTag sequencing, we profiled histone H3K9 lactylation in lesion-infiltrating macrophages and circulating monocytes. Our goal was to identify lactate-driven epigenetic changes that regulate inflammatory gene expression, with a particular focus on TXNIP,NLRP3 inflammasome activation and its impact on mitochondrial function. These data provide a resource for understanding how metabolic reprogramming shapes macrophage immune responses in SCI and may inform the development of epigenetic or metabolic therapeutic strategies for neuroinflammatory disorders.