Gene expression signatures for human non-diabetic (hND) islets and human type 2 diabetes mellitus (hT2DM) islets

We employed a microarray as a discovery platform to identify the differential gene expressions between hND islets and hT2DM islets. 4805 genes with differential expression (fold change >2) were manifested in hT2DM islets. Inflammatory response and immune response were the mostly upregulated biological processes distinguished betwee hND islets and T2DM islets. Results provided insight into the molecular mechanisms in T2DM. Gene expression in human islets was measured after islets were isolated and purified. Human islet samples (>90% purity) were collected from two hND organ donors (sample H046, HE002) and two hT2DM organ donors (sample HE003_Islets, HE005_Islets).