XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608

XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... Authors: Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. Deposit date: 2022-02-15 Release date: 2022-08-10 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13, 2022