Substrate-effector connectivity in 18 proteins.

��Tertiary network�� refers to the contact rearrangement network and ��quaternary network�� refers to the quaternary subgraph of the global communication network (GCNQ). Interdependence is defined as the fraction of observed paths in the GCN that were not observed via either the tertiary or the quaternary network. ��Communication class�� refers to the dominant type of communication in a system, with ��mixed�� meaning that both tertiary and quaternary communication capture 50% or more of the paths and ��interdep�� meaning that interdependence is 50% or higher. ��Hits�� indicates the number of proteins in the set which exhibit connectivity according to two different thresholds. Percent heterotropic paths has been updated from our previous work [12] in a few proteins (see methods for details).aSubstrate binding site determined from a third structure, 4CSM.pdb, with a competitive inhibitor bound at the substrate site.