PDE2a catalytic domain in complex with a brain penetrant inhibitor
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https://pdbj.org/mine/summary/4d08
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PDE2a catalytic domain in complex with a brain penetrant inhibitor Descriptor: 1-(5-butoxypyridin-3-yl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline, CGMP-DEPENDENT 3', 5'-CYCLIC PHOSPHODIESTERASE, ... Authors: Buijnsters, P, Andres, J.I, DeAngelis, M, Langlois, X, Rombouts, F, Sanderson, W, Tresadern, G, Trabanco, A, VanHoof, G, VanRoosbroeck, Y. Deposit date: 2014-04-24 Release date: 2014-08-06 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Based Design of a Potent, Selective, and Brain Penetrating Pde2 Inhibitor with Demonstrated Target Engagement. Acs Med.Chem.Lett., 5, 2014
创建时间：
2014-04-24
