Expression data from SHP specific siRNA or nonspecefic siRNA transfected rat astrocytes

To clarify the effect of SHP in LXRs-mediated signaling pathway, we performed global gene expression analysis of SHP siRNA transfected- or control siRNA transfected- astrocytes after IFN-¿ and LXRs agonist. Microarray analysis revealed that expression of several genes encoding inflammatory mediators were reversed in SHP siRNA transfected-astrocytes, when compared with control siRNA transfected-astrocytes.为阐明SHP在肝X受体（LXRs）介导的信号通路中的作用，我们对经干扰素γ（IFN-γ）及LXRs激动剂处理后的转染SHP小干扰RNA（siRNA）或对照siRNA的星形胶质细胞开展了全基因组表达分析。基因芯片（Microarray）分析结果显示，与转染对照siRNA的星形胶质细胞相比，转染SHP siRNA的星形胶质细胞中多个编码炎症介质的基因表达发生了逆转。