Data underlying the publication "Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress"

The data and resulting publication combine in vivo animal studies on mice, cell biological in vitro experiments and computational modeling to study the role of the intermediate filament protein vimentin as a mechanosensitive regulator of Notch signaling and arterial remodeling. The dataset consists of computational simulation, fluorescence-assisted cell sorting, immunofluorescence and histological staining, luciferase reporter assay, quantitative real-time polymerase chain reaction and Western blotting data.

本数据集及配套发表论文结合小鼠体内动物实验、细胞生物学体外实验与计算建模手段，研究中间丝蛋白波形蛋白（vimentin）作为机械敏感调控因子在Notch信号通路与动脉重塑中的作用。该数据集涵盖计算模拟、荧光辅助细胞分选、免疫荧光与组织化学染色、荧光素酶报告基因检测、实时定量聚合酶链式反应及蛋白质免疫印迹相关实验数据。