data-supporting information for “Pyrrospirones K-Q, Decahydrofluorene-class Alkaloids from the Marine-Derived Fungus Penicillium”
收藏科学数据银行2022-08-30 更新2026-04-23 收录
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https://www.scidb.cn/detail?dataSetId=ee132081211041eca15a8cabe89096de
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资源简介：
Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (1-7), together with six known analogous were isolated from the marine-derived fungal strain Penicillium sp. SCSIO 41512. Their structures were determined by extensive spectroscopic analysis, and their absolute configurations were established by single crystal X-ray diffraction analysis and quantum chemical calculations of electronic circular dichroism (ECD) spectra. Compounds 1 and 2 possessed an unprecedented decahydrofluorene-class alkaloid skeleton with a 6/5/6/8/5/6/13 and a 6/5/6/5/6/13 polycyclic system, respectively. Biologically, 6 and 13 displayed obvious inhibitory activity against protein tyrosine phosphatases SHP1, CD45, PTP1B and TCPTP, and 1, 2, 5, and 8-13 showed antibacterial activity against six pathogens.
提供机构：
Luxinhua; Luolianxiang; 中科院南海所
创建时间：
2022-08-26
