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Total Synthesis of Ellipticine Quinones, Olivacine, and Calothrixin B

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NIAID Data Ecosystem2026-03-08 收录
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A direct route to the synthesis of biologically active ellipticine quinones, olivacine, and calothrixin B is described. The prominent key steps involved are Friedel–Crafts hydroxyalkylation followed by oxidation and directed ortho-lithiation reactions of readily available indole-2-carboxylate esters with appropriately substituted pyridine and quinoline carboxaldehydes.

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2014-01-17
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