Primary and secondary MRI and clinical endpoints in the baseline and treatment periods (mean, standard deviation, range).

P-values are calculated by means of multivariate analysis (MANOVA).��month 0. Abbreviations: SD: standard deviation; w, w/o IFN-��: with/without interferon-beta pre-treatment/comedication; CEL: contrast enhancing lesions; BH: black hole; MTR: magnetization transfer ratio; ADC: apparent diffusion coefficient; NAWM: normal appearing white matter; EDSS: Expanded Disability Status Scale; MSFC: Multiple Sclerosis Functional Composite.