Intention-to-treat analysis comparing treatment groups on primary and secondary outcome measures.

Notes→IRR =  incidence rate-ratio; CI =  confidence interval; AED  =  antiepileptic drug; ED Emergency Departments.
P<0.05 shown in bold; Negative binomial regression used for outcome measure emergency visits and linear regression used for all remaining measures.
IRRs less than 1 here represent a lower visit rate in the ENS intervention group relative to TAU group, whilst IRRs greater than 1, indicate a higher rate.
For secondary outcome measures, positive coefficients here indicate an increase in the score on the outcome variable associated with receiving the ENS led self-management intervention, whilst a negative coefficient the opposite.
Adjustments were made for baseline variables related to outcome at P<0.10:
Emergency department (ED) visits: Baseline Seizure frequency (assessment 3) ED visits (assessments 2, 3), Seizure severity (3), AED number (2,3), Depression (2,3), Anxiety (2,3), Quality of Life (QoL) (3), Felt stigma (3), Medical knowledge (3), Mastery (2,3). Number of covariates in final assessment 2 model = 5; Number of variables in final assessment 3 model = 10.
QoL: Baseline Seizure frequency (2,3), ED visits (2,3), AED number (2), Depression (2,3), Anxiety (2, 3), QoL (2,3), Stigma (2,3), Satisfaction medication information (2), Social knowledge (3), Medical knowledge (3), Mastery (2,3). Number of covariates in final assessment 2 model = 9; Number of covariates in final assessment 3 model = 9.
Seizure frequency: Baseline Seizure frequency (2,3), Primary care seizure-free rate (QOF score 8) (3), Gender (2), ED visits (2,3), Seizure severity (2), AED number (2,3), Depression (2,3), Anxiety (2,3), QoL (2,3), Felt stigma (2,3), Medication management (2), Social knowledge (3), Mastery (2,3). Number of covariates in final assessment 2 model = 11; Number of covariates in final assessment 3 model = 10.
Anxiety: Baseline Seizure frequency (3), ED visits (2,3), AED number (2), Depression (2,3), Anxiety (2,3), QoL (2,3), Felt stigma (2,3), Social knowledge (3), Mastery (2,3). Number of covariates in final assessment 2 model = 7; Number of covariates in final assessment 3 model = 8.
Depression: Baseline Age (3), Education (3), Deprivation (3), ED visits (2,3), Depression (2,3), Anxiety (2,3), QoL (2,3), Felt stigma (2,3), Social knowledge (3), Medical knowledge (3), Satisfaction with medication information (2), Mastery (2,3). Number of covariates in final assessment 2 model = 7; Number of covariates in final assessment 3 model =  11.
Medication Management Skills: Baseline Age (2), Sex (2), Epilepsy duration (2), AED number (3), Depression (3), Medication Management (3), Medical knowledge (3). Number of covariates in adjusted assessment 2 model =  3; Number of covariates in final assessment 3 model = 4.
Mastery: Baseline Seizure frequency (2,3), Gender (2), Ethnicity (3), Deprivation (3), ED visits (2,3), Seizure severity (2,3), AED number (2,3), Depression (2,3), Anxiety (2,3), QoL (2,3), Felt stigma (2,3), Social knowledge (3), Medical knowledge (3), Mastery (2,3). Number of covariates in final assessment 2 model = 10; Number of covariates in final assessment 3 model = 13.
Epilepsy social knowledge: Baseline Age, Education, Deprivation, Medication management skills, Social knowledge, Medical knowledge. Number of covariates in final assessment model = 6.
Epilepsy medical knowledge: Baseline Age, Education, Deprivation, ED visits, Depression, Anxiety, Felt stigma, Social knowledge, Medical knowledge, Mastery. Number of covariates in final assessment model = 10.
Felt stigma: Baseline Seizure frequency, Ethnicity, Deprivation, ED visits, Seizure severity, AED number, Depression, QoL, Felt stigma, Mastery. Number of covariates in final assessment model = 10.
Satisfaction with medication information: Baseline Primary care QOF 8 score, Deprivation, ED visits, Depression, Anxiety, QoL, Felt stigma, Satisfaction with medication information, Medical knowledge, Mastery. Number of covariates in final assessment model = 10.