Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 31

Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 31 Descriptor: 4-[(3~{R})-3-(cyclobutylmethylamino)piperidin-1-yl]-1-[(1~{R})-1-[4-(5-methoxypyridin-3-yl)-1,2,3-triazol-1-yl]ethyl]pyridin-2-one, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit Authors: Dutheuil, G, Oukoloff, K. Deposit date: 2024-07-16 Release date: 2025-02-12 Last modified: 2025-08-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models. J.Med.Chem., 68, 2025