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Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions

NIAID Data Ecosystem2026-05-02 收录

药物诱导基因组变异

利什曼原虫耐药性

数据链接：

https://doi.org/10.7910/DVN/DRM8PK 数据链接链接失效反馈

官方服务：

资源简介：

This data is part of the genome alteration studies of Leishmania orientalis under Amphotericin B inhibiting conditions.

应用场景：

创建时间：

2024-11-30

抗寄生虫药物敏感性

利什曼原虫耐药性

Amphotericin B (AmB) is a recommended medication for the treatment of cutaneous and mucosal leishmaniasis in cases of therapeutic failure with first-line medications; however, little is known about th

Figshare2018-04-27 更新50

MRPA-independent mechanisms of antimony resistance in Leishmania infantum

利什曼原虫耐药性

抗药性机制发现

The ABC transporter MRPA is one of the few key Sb resistance proteins described to date, whose role in detoxification has been thoroughly studied in Leishmania parasites. Nonetheless, its rapid amplif

NIAID Data Ecosystem30

Whole genome sequence analysis of drug sensitive and resistant Leishmania isolates originated from patients of kala-azar.

利什曼原虫耐药性

基因组测序

Visceral leishmaniasis (VL) or kala-azar, caused by Leishmania donovani is the most severe form of leishmaniasis, being fatal if left untreated. Emergence of drug resistant Leishmania parasites has re

NIAID Data Ecosystem30

Characterization of a new mutation confering antimony drug tolerance and resistance in Leishmania parasites

利什曼原虫耐药性

锑类药物作用机制

Background: For almost a century, antimonials have remained the first-line drugs for the treatment of leishmaniasis. However, little is known about their mode of action and clinical resistance mechani

NIAID Data Ecosystem50

Whole genome sequencing of Leishmania donovani parasites resistant to Amphotericin B

利什曼原虫耐药性

Whole genome sequencing of Leishmania donovani parasites resistant to Amphotericin B

NIAID Data Ecosystem30