Ratio (Active MMP-1)/TIMP-1 and TIMP-2.

Measurements were obtained by ELISA for all human small and large diameter varicosities (paired SDv and LDv) and healthy saphenous veins (SV). Values are obtained after division of active MMP-1 values by TIMP-1 and TIMP-2 values normalized per mg of weight tissue. Statistical analysis was performed using one-way-ANOVA followed by the Tukey post-hoc test or by paired t test.*indicates a significant difference (P