Transcriptional profiling of canine osteosarcoma identifies of prognostic gene expression signatures with translational value for humans.

Osteosarcoma is a rare maligancy seen in pediatric human patients but frequently seen in canine patients. Because of the increased frequecy of osteosarcoma in canines it is becoming recognized as an informative model for human osteosarcoma. Therefore in a better effort to understand the moclular features common to both human and canine osteosracoma a transcriptional mRNA seq dataset of 186 canine osteosarcoma primary tumors Primary tumor samples were collected from 186 primary canine osteosarcoma tumors and subsquently sent for transcriptionally profiled using next generation sequencing.