Abundance of cytokines and their correlation with selected metabolites in TB patients, healthy uninfected and latently infected individuals.

(A) Strip charts showing abundances of eight cytokines that differed significantly between the study groups. Significance thresholds for a two-tailed t-test corrected for multiple testing: *, p<0.05; **, p<0.01; ***, p<0.001. Blue line indicates group median, red line indicates group mean. (B) Correlations between metabolic compounds and cytokines. Grey squares, healthy controls (TST–); green circles, latently infected individuals (TST+); brown triangles, active TB patients (TBactive). Spearman correlation coefficient (rho) and p-values are given.