Gold-Catalyzed [1,5]-Hydride Shift onto Unactivated Alkynes To Trigger an Intermolecular Diels–Alder Reaction

A [1,5]-hydride shift of sp3 C–H onto an unactivated carbon–carbon triple bond catalyzed by a gold­(I) complex enabled N-propargylisoindolines to be latent dienes and therefore triggered an intermolecular Diels–Alder reaction with dienophiles. This protocol provides an atom-economical and straightforward approach to access a wide range of polycyclic skeletons in high yields and with excellent diastereoselectivities from easily accessible molecules.