The integrated stress response protects microtubule dynamics to recover from proteotoxic stress

By performing ribosome profiling on squamous cell carcinoma stem cells (either control or S51A mutant) we found that the ISR translationally regulates a network of centrosomal proteins to help cellular recovery upon proteotoxic stress. Overall design: Ribosome profiling and total RNA sequencing were performed on control and S51A cells either vehicle-treated or treated with the proteosome inhibitor bortezomib for 4.5h UPDATE: [Aug-19-2025] The titles, source names, and characteristics for the following Samples were swapped: GSM5823982 <--> GSM5823986 GSM5823983 <--> GSM5823987 GSM5823984 <--> GSM5823988 GSM5823985 <--> GSM5823989 GSM5823998 <--> GSM5824002 GSM5823999 <--> GSM5824003 GSM5824000 <--> GSM5824004 GSM5824001 <--> GSM5824005 The raw data and processed data associated with each GSMxxx did not change.