Human SOD1 over-expressed in motor neurons confers resistance to BMAA treatment.

Shown are survival rates of 35 day-old male sod1 transgenic flies under 3 mM BMAA treatment (10 flies per vial). Panels A, B, and C represent flies expressing mutant human A4V, G85R, and wild type SOD1 proteins, respectively. Like 5 day-old time points (Figure 3, A-C), the SOD1 flies survived longer compared to the controls (CS and dSOD1). The 50% survival rate is increased by 10, 30 and 30% for A4V, G85R, wt SOD1, respectively, when compared to dSOD1 flies. Differences were considered statistically significant if p

本实验展示了在3 mM BMAA处理下，35日龄雄性 sod1转基因果蝇的存活率（每管10只果蝇）。图板A、B和C分别代表表达突变型人源A4V、G85R和野生型SOD1蛋白的果蝇。与5日龄时间点（图3，A-C）类似，SOD1果蝇的存活时间相较于对照组（CS和dSOD1）更长。与dSOD1果蝇相比，A4V、G85R和wt SOD1的50%存活率分别提高了10%、30%和30%。若p值小于显著性水平，则认为差异具有统计学意义。