Processed Seurat objects supporting: p63 and PITX1 sustain a pre-invasive malignant keratinocyte population in squamous cell carcinoma precursors

This dataset contains processed Seurat (v5) objects generated from single-cell CITE-seq analysis of human skin biopsies collected from patients with actinic keratosis (AK), UV-exposed normal skin (UVES), and non-UV-exposed normal skin (NUVES). The objects contain normalized gene expression data, integrated cell metadata, dimensionality reductions, clustering, and cell-type annotations used in the analyses presented in the accompanying manuscript. The dataset supports the identification of AK-specific keratinocytes (ASK), multimodal characterization of keratinocyte populations, differential gene expression analyses, gene signature scoring, regulatory network inference, copy number inference, and integration with spatial transcriptomics.