Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression
收藏Figshare2023-05-25 更新2026-04-28 收录
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https://figshare.com/articles/dataset/Global_Noncoding_microRNA_Profiling_in_Mice_Infected_with_Partial_Human_Mouth_Microbes_PAHMM_Using_an_Ecological_Time-Sequential_Polybacterial_Periodontal_Infection_ETSPPI_Model_Reveals_Sex-Specific_Differential_microRNA_Expression/23199161
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Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. It is more prevalent in males and has poorly understood pathogenic molecular mechanisms. Our primary objective was to characterize alterations in sex-specific microRNA (miRNA, miR) after periodontal bacterial infection. Using partial human mouth microbes (PAHMM) (Streptococcus gordonii, Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia) in an ecological time-sequential polybacterial periodontal infection (ETSPPI) mouse model, we evaluated differential mandibular miRNA profiles by using high-throughput Nanostring nCounter® miRNA expression panels. All PAHMM mice showed bacterial colonization (100%) in the gingival surface, an increase in alveolar bone resorption (p p
创建时间：
2023-05-25
